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KMID : 0363320140350010059
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Journal of Korean Oriental Internal Medicine
2014 Volume.35 No. 1 p.59 ~ p.69
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Effect of Heating Condition and Panax Ginseng on Body Temperature, Hematological Changes, and Immune Response in Rat
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Lee Seo-Ra
Lee In-Hee
Kim Min-Ji
Lew Jae-Hwan
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Abstract
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Objectives : This study was designed to test the effect of heating condition and Panax ginseng on body temperature,
hematologicala changes, and immune response.
Methods : The extract from Panax ginseng was made by the pharmacy department of Kyung Hee Oriental Medical
Hospital. The animals were divided into four groups; control, room temperature Panax ginseng (G), 28 ℃ heating, and 28 ℃ heating Panax ginseng (heating G). Each group has 8 Sprague-Dawley rats. We measured body weight & temperature twice a week. After 2 weeks of experiment, serum lipid level, WBC, differential count, lymphocyte proliferation and immune cytokine concentration were measured.
Results : 1. Simultaneous application of heating condition and Panax ginseng induced decreased body weight and increased body temperature. 2. Simultaneous application of heating condition and Panax ginseng induced decreased AST, ALT and BUN. 3. Simultaneous application of heating condition and Panax ginseng tended to decrease TNF-α concentration, while application of room temperature and Panax ginseng tended to increase TNF-α concentration.
Conclusions : Simultaneous application of heating condition and Panax ginseng decreseas body weight, increases, body
temperature and has a tendency to decrease TNF-α concentration.
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KEYWORD
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heating, Panax ginseng, body weight, body temperature, immune, TNF-α
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